Sickle Cell Disease in Children and Adolescents

Clinical Practice Guidelines

(Adapted from the Hospital for Sick Children) 

January 2024

• Acute Chest Syndrome or Pneumonia: Guidelines for Management in Children with Sickle Cell Disease

• Acute Splenic Sequestration: Guidelines for Management in Children with Sickle Cell Disease

• Acute Painful Episodes Vaso-occlusive Crisis: Guidelines for Management in Children with Sickle Cell Disease

• Stroke: Guidelines for Management in Children with Sickle Cell Disease

• Initial Management of Sickle Cell Disease (SCD) – ED Pathway

**The following PPOs have been adapted by APPHON/ROHPPA with permission of the IWK**

Pre-Printed Orders

• Sickle Cell Disease and/or Asplenia with Fever or Acute Illness ED/Clinic Management Greater than 1 Month Old
• Sickle Cell Disease and/or Asplenia with Fever or Acute Illness Greater than 1 Month Old Pediatric Admission Orders
• Management of Children with Sickle Cell Disease and/or Asplenia with Fever or Acute Illness Greater than 1 Month Old Outpatient Follow-Up
• Sickle Cell Disease Acute Chest Syndrome Orders Greater than 1 Month Old
• Sickle Cell Disease Pain Admission Orders Greater than 6 Months Old High Alert
• Hydromorphone Continuous Infusion High Alert
• Morphine Continuous Infusion High Alert 

• Guidelines for the Management of ACUTE ILLNESS or FEVER in Children with SICKLE CELL DISEASE Treat Promptly Card 
• Guidelines for the Management of ACUTE ILLNESS or FEVER in Children with ASPLENIA or HYPOSPLENIA Treat Promptly Card

**The Vaccine Schedules document has been adapted by APPHON/ROHPPA with permission from the authors of the CPS statement.**

Vaccine Schedules

• Vaccine Schedules for Children with Sickle Cell Disease and Asplenia